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Advances in Targeting IKK and IKK-Related Kinases for Cancer Therapy

14 Sept 2008

Abstract excerpt

IkappaB kinases (IKK) and IKK-related kinases play critical roles in regulating the immune response through nuclear factor-kappaB and IFN regulatory factor-dependent signaling transduction cascades. Recently, these kinases have been implicated in the pathogenesis of many human diseases, including cancer. In fact, dysregulation of IKK activities promotes tumor survival, proliferation, migration, metastasis, and...

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PMID: 18794072
DOI: 10.1158/1078-0432.ccr-08-0123

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