Article

TFEB degradation is regulated by an IKK/β-TrCP2 phosphorylation-ubiquitination cascade

2023-10-19

Abstract excerpt

<h4>ABSTRACT</h4> Transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis and autophagy that plays a key role in the regulation of cellular clearance pathways. TFEB is regulated via a complex array of post-translational modifications (PTMs), but the exact molecular mechanism that regulates TFEB stability has remained elusive. Here, we show that TFEB levels are critically regulated by a define...

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Literature Corpus work: 21788212-518e-57f9-9311-8d0b9ecd0dcf
DOI: 10.1101/2023.10.16.562572

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