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Article

IκB kinase β (IKKβ) inhibits p63 isoform γ (TAp63γ) transcriptional activity.

The Journal of biological chemistry - 21 Jun 2013

Liao Jun-Ming, Zhang Yu, Liao Wenjuan, Zeng Sheyla X, Su Xiaohua, Flores Elsa R, Lu Hua

Abstract excerpt

Previously, we reported that IκB kinase-β(IKKβ) phosphorylates and stabilizes TAp63γ. However, the effect of this phosphorylation on TAp63γ transcriptional activity remains unclear. In this study, we showed that overexpression of IKKβ, but not its kinase dead mutant and IKKα, can surprisingly inhibit TAp63γ transcriptional activity as measured by luciferase assays and real-time PCR analyses of p63 target genes....

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Identifiers

PMID: 23589370
DOI: 10.1074/jbc.M113.466540
PMCID: PMC3689961

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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