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Article

Efficient internalization of MHC I requires lysine-11 and lysine-63 mixed linkage polyubiquitin chains.

Traffic (Copenhagen, Denmark) - 1 Feb 2010

Boname Jessica M, Thomas Mair, Stagg Helen R, Xu Ping, Peng Junmin, Lehner Paul J

Abstract excerpt

The downregulation of cell surface receptors by endocytosis is a fundamental requirement for the termination of signalling responses and ubiquitination is a critical regulatory step in receptor regulation. The K5 gene product of Kaposi's sarcoma-associated herpesvirus is an E3 ligase that ubiquitinates and downregulates several cell surface immunoreceptors, including major histocompatibility complex (MHC) class I...

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Share to Endocytosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19948006
DOI: 10.1111/j.1600-0854.2009.01011.x
PMCID: PMC3551259

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