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Article

Identification of TRAF6-dependent NEMO polyubiquitination sites through analysis of a new NEMO mutation causing incontinentia pigmenti.

Human molecular genetics - 1 Dec 2007

Sebban-Benin Hélène, Pescatore Alessandra, Fusco Francesca, Pascuale Valérie, Gautheron Jérémie, Yamaoka Shoji, Moncla Anne, Ursini Matilde Valeria, Courtois Gilles

Abstract excerpt

The regulatory subunit NEMO is involved in the mechanism of activation of IkappaB kinase (IKK), the kinase complex that controls the NF-kappaB signaling pathway. During this process, NEMO is modified post-translationally through K63-linked polyubiquitination. We report the molecular characterization of a new missense mutation of NEMO (A323P) which causes a severe form of incontinentia pigmenti (OMIM#308300), an...

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Share to I-kappa B Kinase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17728323
DOI: 10.1093/hmg/ddm237

Genes

TRAF6
TNF
LPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Identification of TRAF6-dependent NEMO polyubiquitination sites through analysis of a new NEMO mutation causing incontinentia pigmenti.PMID 17728323Read ↗

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