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Article

ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB.

The Journal of biological chemistry - 7 Jul 2006

Mauro Claudio, Pacifico Francesco, Lavorgna Alfonso, Mellone Stefano, Iannetti Alessio, Acquaviva Renato, Formisano Silvestro, Vito Pasquale, Leonardi Antonio

Abstract excerpt

Nuclear factor kappaB (NF-kappaB) plays a pivotal role in inflammation, immunity, stress responses, and protection from apoptosis. Canonical activation of NF-kappaB is dependent on the phosphorylation of the inhibitory subunit IkappaBalpha that is mediated by a multimeric, high molecular weight complex, called IkappaB kinase (IKK) complex. This is composed of two catalytic subunits, IKKalpha and IKKbeta, and a...

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Identifiers

PMID: 16684768
DOI: 10.1074/jbc.M601502200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB.PMID 16684768Read ↗

Structure-function analysis of the A20-binding inhibitor of NF-kappa B activation, ABIN-1.Semantic proximity Read ↗

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The Ubiquitin System and A20: Implications in Health and DiseaseSemantic proximity Read ↗

Regulation of NF-κB activity by competition between RelA acetylation and ubiquitination.Semantic proximity Read ↗

Ubiquitin-binding domain in ABIN1 is critical for regulating cell death and inflammation during developmentSemantic proximity Read ↗

A20 in inflammation and autoimmunity.Semantic proximity Read ↗

Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding–Defective Mutant of ABIN1Semantic proximity Read ↗

The IKK complex, a central regulator of NF-kappaB activation.Semantic proximity Read ↗

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Analysis of nuclear factor-κB (NF-κB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB.Semantic proximity Read ↗

The Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseasesSemantic proximity Read ↗

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