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Article

IkappaB kinase beta promotes cell survival by antagonizing p53 functions through DeltaNp73alpha phosphorylation and stabilization.

Molecular and cellular biology - 1 Jun 2011

Accardi Rosita, Scalise Mariafrancesca, Gheit Tarik, Hussain Ishraq, Yue Jiping, Carreira Christine, Collino Agnese, Indiveri Cesare, Gissmann Lutz, Sylla Bakary S, Tommasino Massimo

Abstract excerpt

ΔNp73α, a dominant-negative inhibitor of p53 and p73, exhibits antiapoptotic and transforming activity in in vitro models and is often found to be upregulated in human cancers. The mechanisms involved in the regulation of ΔNp73α protein levels in normal and cancer cells are poorly characterized. Here, we show that that IκB kinase beta (IKKβ) increases ΔNp73α protein stability independently of its ability to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21482671
DOI: 10.1128/MCB.00964-10
PMCID: PMC3133237

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