Article
The inflammatory kinase IKKα phosphorylates and stabilizes c-Myc and enhances its activity.
Molecular cancer - 18 Jan 2021
Moser Bernhard, Hochreiter Bernhard, Basílio José, Gleitsmann Viola, Panhuber Anja, Pardo-Garcia Alan, Hoesel Bastian, Salzmann Manuel, Resch Ulrike, Noreen Mamoona, Schmid Johannes A
Abstract excerpt
BACKGROUND: The IκB kinase (IKK) complex, comprising the two enzymes IKKα and IKKβ, is the main activator of the inflammatory transcription factor NF-κB, which is constitutively active in many cancers. While several connections between NF-κB signaling and the oncogene c-Myc have been shown, functional links between the signaling molecules are still poorly studied. METHODS: Molecular interactions were shown by...
Topics
- Amino Acid Sequence
- Animals
- Apoptosis
- Cell Line, Tumor
- Cell Nucleus
- Cell Proliferation
- HEK293 Cells
- Humans
- I-kappa B Kinase
- Inflammation
- Male