Article
ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress.
Molecular cell - 8 Oct 2010
Wu Zhao-Hui, Wong Ee Tsin, Shi Yuling, Niu Jixiao, Chen Zhijian, Miyamoto Shigeki, Tergaonkar Vinay
Abstract excerpt
Activation of the transcription factor NF-κB by multiple genotoxic stimuli modulates cancer cell survival. This response is mediated by a conserved pathway involving the nuclear ATM kinase and cytoplasmic IκB kinase (IKK); however, the molecular link between them remains incompletely understood. Here we show that ATM activates the IKK kinase TAK1 in a manner dependent on IKKγ/NEMO and ELKS (a protein rich in...
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