Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cell-surface MHC density profiling reveals instability of autoimmunity-associated HLA.

The Journal of clinical investigation - 1 Jan 2015

Miyadera Hiroko, Ohashi Jun, Lernmark Åke, Kitamura Toshio, Tokunaga Katsushi

Abstract excerpt

Polymorphisms within HLA gene loci are strongly associated with susceptibility to autoimmune disorders; however, it is not clear how genetic variations in these loci confer a disease risk. Here, we devised a cell-surface MHC expression assay to detect allelic differences in the intrinsic stabilit...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Case-Control Studies
Share to Cell Membrane

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

Share to Evolution, Molecular

Share to HLA-DQ Antigens

Share to NIH 3T3 Cells

Share to Protein Stability

Source

Open in PubMed Open full text

Identifiers

PMID: 25485681
DOI: 10.1172/JCI74961
PMCID: PMC4382229

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25485681-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cell-surface MHC density profiling reveals instability of autoimmunity-associated HLA.PMID 25485681Read ↗

The genetics of HLA-associated disease.Semantic proximity Read ↗

Next-Generation HLA Sequence Analysis Uncovers Seven HLA-DQ Amino Acid Residues and Six Motifs Resistant to Childhood Type 1 Diabetes.Semantic proximity Read ↗

Structural factors contributing to DM susceptibility of MHC class II/peptide complexes.Semantic proximity Read ↗

A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins.Semantic proximity Read ↗

Progression to type 1 diabetes in the DPT-1 and TN07 clinical trials is critically associated with specific residues in HLA-DQA1-B1 heterodimers.Semantic proximity Read ↗

Exploring the diabetogenicity of the HLA-B18-DR3 CEH: independent association with T1D genetic risk close to HLA-DOA.Semantic proximity Read ↗

Avidity-dependent programming of autoreactive T cells in T1D.Semantic proximity Read ↗

Exceptional stability of the HLA-DQA1*0102/DQB1*0602 alpha beta protein dimer, the class II MHC molecule associated with protection from insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Human leukocyte Antigen-DM polymorphisms in autoimmune diseases.Semantic proximity Read ↗

The Limitation of HLA Diversity as a Risk Factor for Pediatric-Onset Autoimmune Rheumatic DiseaseSemantic proximity Read ↗

MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchangeSemantic proximity Read ↗

HLA-DQA1 and HLA-DQB1 Alleles, Conferring Susceptibility to Celiac Disease and Type 1 Diabetes, Are More Expressed Than Non-Predisposing Alleles and Are Coordinately RegulatedSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.