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Article

Progression to type 1 diabetes in the DPT-1 and TN07 clinical trials is critically associated with specific residues in HLA-DQA1-B1 heterodimers.

Diabetologia - 1 Nov 2024

Zhao Lue Ping, Papadopoulos George K, Skyler Jay S, Pugliese Alberto, Parikh Hemang M, Kwok William W, Lybrand Terry P, Bondinas George P, Moustakas Antonis K, Wang Ruihan, Pyo Chul-Woo, Nelson Wyatt C, Geraghty Daniel E, Lernmark Åke

Abstract excerpt

AIMS/HYPOTHESIS: The aim of this work was to explore molecular amino acids (AAs) and related structures of HLA-DQA1-DQB1 that underlie its contribution to the progression from stages 1 or 2 to stage 3 type 1 diabetes. METHODS: Using high-resolution DQA1 and DQB1 genotypes from 1216 participants in the Diabetes Prevention Trial-Type 1 and the Diabetes Prevention Trial, we applied hierarchically organised haplotype...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39354095
DOI: 10.1007/s00125-024-06274-6
PMCID: PMC11519105

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