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Article

Avidity-dependent programming of autoreactive T cells in T1D.

PloS one - 1 Jan 2014

Durinovic-Belló Ivana, Gersuk Vivian H, Ni Chester, Wu Rebecca, Thorpe Jerill, Jospe Nicholas, Sanda Srinath, Greenbaum Carla J, Nepom Gerald T

Abstract excerpt

Fate determination for autoreactive T cells relies on a series of avidity-dependent interactions during T cell selection, represented by two general types of signals, one based on antigen expression and density during T cell development, and one based on genes that interpret the avidity of TCR interaction to guide developmental outcome. We used proinsulin-specific HLA class II tetramers to purify and determine...

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Share to Autoantigens
Share to Autoimmunity
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proinsulin

Share to Receptors, Antigen, T-Cell

Share to T-Cell Antigen Receptor Specificity

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Source

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Identifiers

PMID: 24844227
DOI: 10.1371/journal.pone.0098074
PMCID: PMC4028311

Genes

INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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