Article
A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins.
Human molecular genetics - 15 Sept 2001
Cucca F, Lampis R, Congia M, Angius E, Nutland S, Bain S C, Barnett A H, Todd J A
Abstract excerpt
In human type 1 diabetes (T1D) and in its murine model, the major histocompatibility complex (MHC) class II molecules, human leukocyte antigens (HLA)-DQ and -DR and their murine orthologues, IA and IE, are the major genetic determinants. In this report, we have ranked HLA class II molecule-associated T1D risk in a two-sided gradient from very high to very low. Very low risk corresponded to dominant protection...
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