Exceptional stability of the HLA-DQA1*0102/DQB1*0602 alpha beta protein dimer, the class II MHC molecule associated with protection from insulin-dependent diabetes mellitus.

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Article

Exceptional stability of the HLA-DQA10102/DQB10602 alpha beta protein dimer, the class II MHC molecule associated with protection from insulin-dependent diabetes mellitus.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1998

Ettinger R A, Liu A W, Nepom G T, Kwok W W

Abstract excerpt

HLA-DQ alleles are closely associated with susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM) but the immunologic mechanisms involved are not understood. Structural studies of the IDDM-susceptible allele, HLA-DQA1*0301/DQB1*0302, have classified it as a relatively unstabl...

Topics

Alleles
B-Lymphocytes
Cell Line, Transformed
Diabetes Mellitus, Type 1
Dimerization
Genetic Predisposition to Disease
HLA-DQ Antigens
HLA-DQ alpha-Chains
HLA-DQ beta-Chains
Herpesvirus 4, Human
Humans
Protein Denaturation
Sodium Dodecyl Sulfate

Source

Open in PubMed

Identifiers

PMID: 9834137

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9834137-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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