Article
The genetics of HLA-associated disease.
Current opinion in immunology - 1 Oct 2004
Larsen Charles E, Alper Chester A
Abstract excerpt
Type 1 diabetes mellitus (T1D) remains the most intensively studied, and thus the best paradigm, of MHC-associated diseases. Accumulating evidence suggests that MHC susceptibility for T1D is recessive, with susceptibility alleles more common than protective alleles. Updated allele-level and nucleotide sequence analysis of MHC class II T1D susceptibility markers of conserved extended haplotypes underscore the...
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