Article

The Limitation of HLA Diversity as a Risk Factor for Pediatric-Onset Autoimmune Rheumatic Disease

2024-11-22

Abstract excerpt

HLA homozygosity of specific alleles at a single locus is associated with increased risk for autoimmunity. However, the contribution of the overall limitation of HLA allele diversity to autoimmunity risk remains to be determined. We conducted a proof-of-concept case-control study of 413 subjects (279 cases, 134 matched controls) examining the “Limitation of HLA Diversity” (LoHLAD) across multiple loci as an allele...

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Literature Corpus work: aa1a76a7-cf64-56b4-8601-1c71e069533f
DOI: 10.20944/preprints202411.1694.v1

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