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Article

Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy.

The Journal of infectious diseases - 1 Dec 2006

Izzedine Hassane, Hulot Jean-Sebastien, Villard Eric, Goyenvalle Catherine, Dominguez Stephanie, Ghosn Jade, Valantin Marc Antoine, Lechat Philippe, Deray And Gilbert

Abstract excerpt

BACKGROUND: Tenofovir disoproxil fumarate (TDF) may induce renal proximal tubulopathy (rPT). There are no data on pharmacogenomic predictors of rPT in the genes encoding the multidrug-resistance protein (MRP) 2 and MRP4 transporters. METHODS: Mutational screening of the genes for MRP2 (ABCC2) and MRP4 (ABCC4) was performed using genomic DNA from 13 human immunodeficiency virus type 1 (HIV-1)-infected patients...

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Source

Identifiers

PMID: 17083032
DOI: 10.1086/508546

Genes

ABCC2
ABCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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