Article
Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1).
Pharmacogenetics and genomics - 1 Apr 2005
Fujita Tomoe, Brown Chaline, Carlson Elaine J, Taylor Travis, de la Cruz Melanie, Johns Susan J, Stryke Doug, Kawamoto Michiko, Fujita Kazumi, Castro Richard, Chen Chung-Wen, Lin Emil T, Brett Claire M, Burchard Esteban Gonzalez, Ferrin Thomas E, Huang Conrad C, Leabman Maya K, Giacomini Kathleen M
Abstract excerpt
OBJECTIVES: The organic anion transporter, OAT1 (SLC22A6), plays a role in the renal elimination of many drugs and environmental toxins. The goal of this study was to identify and functionally characterize OAT1 variants as a first step towards understanding whether genetic variation in OAT1 may contribute to interindividual differences in renal elimination of xenobiotics. METHODS: As part of a larger study, 276...
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