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Article

The interaction between hepatitis B virus X protein and AIB1 oncogene is required for the activation of NFκB signal transduction.

Biochemical and biophysical research communications - 22 Jun 2012

Hong Andy, Han Dong Dong, Wright Christine J, Burch Tanya, Piper Jessica, Osiowy Carla, Gao Chunjin, Chiang Shirley, Magill Travis, Dick Kevin, Booth Timothy F, Li Xuguang, He Runtao

Abstract excerpt

We identified the interaction between HBV X (HBx) protein and the oncogene AIB1 (amplified in breast cancer 1). A serine/proline motif (SSPSPS) in HBx was found to be required for the interaction. Two LXD motifs [LLXX(X)L, X means any amino acids], LLRNSL and LLDQLHTLL in AIB1 were also found to be involved in the HBx-AIB1 interaction. The HBx-AIB1 interaction was important for the activation of NFκB signal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22627138
DOI: 10.1016/j.bbrc.2012.05.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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