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Article

HBV X protein mutations affect HBV transcription and association of histone-modifying enzymes with covalently closed circular DNA.

Scientific reports - 21 Jan 2020

Chong Chun Kong, Cheng Ching Yan Serene, Tsoi Sin Yi Jasmine, Huang Fung-Yu, Liu Fen, Fung James, Seto Wai-Kay, Lai Keane K-Y, Lai Ching-Lung, Yuen Man-Fung, Wong Danny Ka-Ho

Abstract excerpt

The hepatitis B X protein (HBx) plays a role in the epigenetic regulation of hepatitis B virus (HBV) replication. This study investigated the effects of HBx mutations on HBV transcription and the recruitment of HBx, histone acetyl-transferase P300 and histone deacetylase 1 (HDAC1) to circularized HBV DNA (which resembles covalently closed circular DNA [cccDNA]). Compared with wild type, majority of mutants had...

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Identifiers

PMID: 31964944
DOI: 10.1038/s41598-020-57637-z
PMCID: PMC6972884

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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