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Article

Hepatitis B virus X protein interferes with cellular DNA repair.

Journal of virology - 1 Jan 1998

Becker S A, Lee T H, Butel J S, Slagle B L

Abstract excerpt

The hepatitis B virus X protein (HBx) is a broadly acting transactivator implicated in the development of liver cancer. Recently, HBx has been reported to interact with several different cellular proteins, including our report of its binding to XAP-1, the human homolog of the simian repair protein UVDDB. In the present study, several HBx mutants were used to localize the minimal domain of HBx required for binding...

Topics

Animals
Binding Sites
Carcinoma, Hepatocellular
DNA Damage
DNA Repair
DNA-Binding Proteins
Genes, Viral
Hepatitis B virus
Humans
Liver Neoplasms
Mutation
Protein Binding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Trans-Activators

Tumor Cells, Cultured

Ultraviolet Rays

Viral Proteins

Viral Regulatory and Accessory Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 9420223
DOI: 10.1128/JVI.72.1.266-272.1998
PMCID: PMC109372

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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