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Article

Histaminergic transmission slows progression of amyotrophic lateral sclerosis

24 Apr 2019

Abstract excerpt

BACKGROUND: Histamine is an immune modulator, neuroprotective, and remyelinating agent, beneficially acting on skeletal muscles and promoting anti-inflammatory features in amyotrophic lateral sclerosis (ALS) microglia. Drugs potentiating the endogenous release of histamine are in trial for neurological diseases, with a role not systematically investigated in ALS. Here, we examine histamine pathway associations in...

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PMID: 31020811
DOI: 10.1002/jcsm.12422

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