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Article

Bromocriptine methylate suppresses glial inflammation and moderates disease progression in a mouse model of amyotrophic lateral sclerosis.

Experimental neurology - 1 Nov 2011

Tanaka Kazunori, Kanno Takuya, Yanagisawa Yoshiko, Yasutake Kaori, Hadano Shinji, Yoshii Fumihito, Ikeda Joh-E

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by a selective loss of upper and lower motor neurons. Since oxidative stress plays a crucial role in the progression of motor neuron loss observed in ALS, anti-oxidative agents could be an important therapeutic means for the ALS treatment. We have previously developed a drug screening system allowing the identification...

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Identifiers

PMID: 21867702
DOI: 10.1016/j.expneurol.2011.08.001

Genes

SOD1
NAIP
TNF
ATF3

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