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The application of CRISPR/Cas9–based genome-wide screening to disease research

21 Dec 2024

Abstract excerpt

High-throughput genetic screening serves as an indispensable approach for deciphering gene functions and the intricate relationships between phenotypes and genotypes. The CRISPR/Cas9 system, with its ability to precisely edit genomes on a large scale, has revolutionized the field by enabling the construction of comprehensive genomic libraries. This technology has become a cornerstone for genome-wide screenings in...

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PMID: 39709065
DOI: 10.1016/j.mcp.2024.102004

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