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Association between methylation of BIN1 promoter in peripheral blood and preclinical Alzheimer’s disease

2 Feb 2021

Abstract excerpt

The bridging integrator 1 (BIN1) gene is the second most important susceptibility gene for late-onset Alzheimer's disease (LOAD) after apolipoprotein E (APOE) gene. To explore whether the BIN1 methylation in peripheral blood changed in the early stage of LOAD, we included 814 participants (484 cognitively normal participants [CN] and 330 participants with subjective cognitive decline [SCD]) from the Chinese...

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PMID: 33531457
DOI: 10.1038/s41398-021-01218-9

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