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Article

Application of rapid genotyping of Warfarin individualized pharmacogenetic variants in Warfarin therapy.

Scientific reports - 30 Dec 2024

Huang Defa, Xie Fangfang, Xiao Shengpeng, Cai Minyang, Hu Die, Ling Baodian, Wang Fangsheng, Lin Xuan, Song Fangli, Wang Qi, Zhong Tianyu

Abstract excerpt

Warfarin is the most widely used oral anticoagulant in clinical practice. The cytochrome P450 2C9 (CYP2C9), vitamin K epoxide reductase complex 1 (VKORC1), and cytochrome P450 4F2 (CYP4F2) genotypes are associated with warfarin dose requirements in China. Accurate genotyping is vital for obtaining reliable genotype-guided warfarin dosing information. The current method for individualized dosing gene polymorphism...

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Identifiers

PMID: 39738187
DOI: 10.1038/s41598-024-80639-0
PMCID: PMC11686395

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