Article
Thrombin receptor deficiency leads to a high bone mass phenotype by decreasing the RANKL/OPG ratio.
Bone - 1 Mar 2015
Tudpor Kukiat, van der Eerden Bram C J, Jongwattanapisan Prapaporn, Roelofs Joris J T H, van Leeuwen Johannes P T M, Bindels René J M, Hoenderop Joost G J
Abstract excerpt
Thrombin and its receptor (TR) are, respectively, expressed in osteoclasts and osteoblasts. However, their physiological roles on bone metabolism have not been fully elucidated. Here we investigated the bone microarchitecture by micro-computed tomography (μCT) and demonstrated increased trabecular and cortical bone mass in femurs of TR KO mice compared to WT littermates. Trabecular thickness and connectivity were...
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