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Article

Contrasting skeletal phenotypes in mice with an identical mutation targeted to thyroid hormone receptor alpha1 or beta.

Molecular endocrinology (Baltimore, Md.) - 1 Dec 2005

O'Shea Patrick J, Bassett J H Duncan, Sriskantharajah Srividya, Ying Hao, Cheng Sheue-yann, Williams Graham R

Abstract excerpt

Thyroid hormone (T(3)) regulates bone turnover and mineralization in adults and is essential for skeletal development. Surprisingly, we identified a phenotype of skeletal thyrotoxicosis in T(3) receptor beta(PV) (TRbeta(PV)) mice in which a targeted frameshift mutation in TRbeta results in resistance to thyroid hormone. To characterize mechanisms underlying thyroid hormone action in bone, we analyzed skeletal...

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Source

Identifiers

PMID: 16051666
DOI: 10.1210/me.2005-0224

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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