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Article

Physiological function of the angiotensin AT1a receptor in bone remodeling.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Dec 2011

Kaneko Keiko, Ito Masako, Fumoto Toshio, Fukuhara Ryoji, Ishida Junji, Fukamizu Akiyoshi, Ikeda Kyoji

Abstract excerpt

In order to determine whether the renin-angiotensin system (RAS) has any physiologic function in bone metabolism, mice lacking the gene encoding the major angiotensin II receptor isoform, AT1a, were studied using micro CT scanning, histomorphometric, and biochemical techniques. Three-dimensional (3D) micro CT analysis of the tibial metaphysis revealed that both male and female AT1a knockout mice exhibited an...

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PMID: 21887703
DOI: 10.1002/jbmr.501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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