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Article

Novel Genetic Models of Osteoporosis by Overexpression of Human RANKL in Transgenic Mice

11 Oct 2013

Abstract excerpt

Receptor activator of NF-κB ligand (RANKL) plays a key role in osteoclast-induced bone resorption across a range of degenerative bone diseases, and its specific inhibition has been recently approved as a treatment for women with postmenopausal osteoporosis at high or increased risk of fracture in the United States and globally. In the present study, we generated transgenic mice (TghuRANKL) carrying the human...

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PMID: 24127173
DOI: 10.1002/jbmr.2112

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