Article
Mast Cells Are Critical Regulators of Bone Fracture-Induced Inflammation and Osteoclast Formation and Activity.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Dec 2017
Kroner Jochen, Kovtun Anna, Kemmler Julia, Messmann Joanna J, Strauss Gudrun, Seitz Sebastian, Schinke Thorsten, Amling Michael, Kotrba Johanna, Froebel Julia, Dudeck Jan, Dudeck Anne, Ignatius Anita
Abstract excerpt
Mast cells, important sensor and effector cells of the immune system, may influence bone metabolism as their number is increased in osteoporotic patients. They are also present during bone fracture healing with currently unknown functions. Using a novel c-Kit-independent mouse model of mast cell deficiency, we demonstrated that mast cells did not affect physiological bone turnover. However, they triggered local...
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