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Article

Hyperthyroid-associated osteoporosis is exacerbated by the loss of TSH signaling.

The Journal of clinical investigation - 1 Oct 2012

Baliram Ramkumarie, Sun Li, Cao Jay, Li Jianhua, Latif Rauf, Huber Amanda K, Yuen Tony, Blair Harry C, Zaidi Mone, Davies Terry F

Abstract excerpt

The osteoporosis associated with human hyperthyroidism has traditionally been attributed to elevated thyroid hormone levels. There is evidence, however, that thyroid-stimulating hormone (TSH), which is low in most hyperthyroid states, directly affects the skeleton. Importantly, Tshr-knockout mice...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22996689
DOI: 10.1172/JCI63948
PMCID: PMC3461920

Genes

TSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22996689-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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