Article
The transcriptional repressor CTBP-1 functions in the nervous system of Caenorhabditis elegans to regulate lifespan.
Experimental gerontology - 1 Dec 2014
Reid Anna, Yücel Duygu, Wood Mallory, Llamosas Estelle, Kant Sashi, Crossley Merlin, Nicholas Hannah
Abstract excerpt
C-terminal binding proteins (CtBPs) are recruited by a variety of transcription factors to mediate gene repression. Nematode CTBP-1 has previously been shown to play a role in the regulation of lifespan; Caenorhabditis elegans strains carrying a deletion in the ctbp-1 gene showed a 10-20% increase in mean and maximal lifespan compared with wild-type control strains. We set out to identify the tissues in which...
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