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Article

The R148.3 Gene Modulates Caenorhabditis elegans Lifespan and Fat Metabolism.

G3 (Bethesda, Md.) - 7 Aug 2017

Roy-Bellavance Catherine, Grants Jennifer M, Miard Stéphanie, Lee Kayoung, Rondeau Évelyne, Guillemette Chantal, Simard Martin J, Taubert Stefan, Picard Frédéric

Abstract excerpt

Despite many advances, the molecular links between energy metabolism and longevity are not well understood. Here, we have used the nematode model Caenorhabditis elegans to study the role of the yet-uncharacterized gene R148.3 in fat accumulation and lifespan. In wild-type worms, a R148.3p::GFP reporter showed enhanced expression throughout life in the pharynx, in neurons, and in muscles. Functionally, a protein...

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Identifiers

PMID: 28620088
DOI: 10.1534/g3.117.041681
PMCID: PMC5555478

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