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Article

Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes.

Nature - 16 Jan 2003

Ashrafi Kaveh, Chang Francesca Y, Watts Jennifer L, Fraser Andrew G, Kamath Ravi S, Ahringer Julie, Ruvkun Gary

Abstract excerpt

Regulation of body fat storage involves signalling between centres that regulate feeding in the brain and sites of fat storage and use in the body. Here we describe an assay for analysing fat storage and mobilization in living Caenorhabditis elegans. By using RNA-mediated interference (RNAi) to disrupt the expression of each of the 16,757 worm genes, we have systematically screened the C. elegans genome for genes...

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PMID: 12529643
DOI: 10.1038/nature01279

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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