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Article

C elegans: a model for exploring the genetics of fat storage.

Developmental cell - 1 Jan 2003

McKay Renée M, McKay James P, Avery Leon, Graff Jonathan M

Abstract excerpt

To gain insights into the genetic cascades that regulate fat biology, we evaluated C. elegans as an appropriate model organism. We generated worms that lack two transcription factors, SREBP and C/EBP, crucial for formation of mammalian fat. Worms deficient in either of these genes displayed a lipid-depleted phenotype-pale, skinny, larval-arrested worms that lack fat stores. On the basis of this phenotype, we used...

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Identifiers

PMID: 12530969
DOI: 10.1016/s1534-5807(02)00411-2
PMCID: PMC4445237

Genes

EBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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