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Article

IL-17 undermines longevity and stress tolerance by inhibiting a protective transcriptional network

2023-01-13

Abstract excerpt

Aberrant cytokine secretion contributes to the pathogenesis of autoimmune diseases and age-related disorders, but the molecular mechanism underlying this is not entirely clear. Here, we elucidate how interleukin-17 (IL-17) overactivation shortens lifespan and damages defense mechanisms against stress in C. elegans . Our analysis reveals that NHR-49, the C. elegans ortholog of human PPARα and HNF4, is the central...

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Identifiers and source

Literature Corpus work
0bffa156-712f-5213-abc5-22b7be698016
DOI
10.1101/2023.01.13.523898
Open publication

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IL-17 undermines longevity and stress tolerance by inhibiting a protective transcriptional networkDOI 10.1101/2023.01.13.523898
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