Article
BCL2 mutations are associated with increased risk of transformation and shortened survival in follicular lymphoma.
Blood - 22 Jan 2015
Correia Cristina, Schneider Paula A, Dai Haiming, Dogan Ahmet, Maurer Matthew J, Church Amy K, Novak Anne J, Feldman Andrew L, Wu Xiaosheng, Ding Husheng, Meng X Wei, Cerhan James R, Slager Susan L, Macon William R, Habermann Thomas M, Karp Judith E, Gore Steven D, Kay Neil E, Jelinek Diane F, Witzig Thomas E, Nowakowski Grzegorz S, Kaufmann Scott H
Abstract excerpt
Follicular lymphoma (FL), an indolent neoplasm caused by a t(14;18) chromosomal translocation that juxtaposes the BCL2 gene and immunoglobulin locus, has a variable clinical course and frequently undergoes transformation to an aggressive lymphoma. Although BCL2 mutations have been previously described, their relationship to FL progression remains unclear. In this study, we evaluated the frequency and nature of...
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