Article
Somatic mutations of the translocated bcl-2 gene are associated with morphologic transformation of follicular lymphoma to diffuse large-cell lymphoma.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jan 1997
Matolcsy A, Warnke R A, Knowles D M
Abstract excerpt
BACKGROUND: Ninety percent of low-grade follicular lymphomas (FLs) carry the t(14;18) translocation. This event juxtaposes the bcl-2 oncogene to the immunoglobulin (Ig) heavy-chain gene and leads to bcl-2 gene overexpression. Morphologic transformation of FL to high-grade lymphoma is associated w...
Topics
- Base Sequence
- Cell Transformation, Neoplastic
- Chromosomes, Human, Pair 14
- Chromosomes, Human, Pair 18
- Genes, bcl-2
- Humans
- Lymphoma, Follicular
- Lymphoma, Large B-Cell, Diffuse
- Molecular Sequence Data
- Mutation
- Translocation, Genetic