Article
Relationship between BCL2 mutations and follicular lymphoma outcome in the chemoimmunotherapy era.
Blood cancer journal - 17 May 2023
Correia Cristina, Maurer Matthew J, McDonough Samantha J, Schneider Paula A, Ross Paige E, Novak Anne J, Feldman Andrew L, Cerhan James R, Slager Susan L, Witzig Thomas E, Eckloff Bruce W, Li Hu, Nowakowski Grzegorz S, Kaufmann Scott H
Abstract excerpt
How to identify follicular lymphoma (FL) patients with low disease burden but high risk for early progression is unclear. Building on a prior study demonstrating the early transformation of FLs with high variant allele frequency (VAF) BCL2 mutations at activation-induced cytidine deaminase (AICDA) sites, we examined 11 AICDA mutational targets, including BCL2, BCL6, PAX5, PIM1, RHOH, SOCS, and MYC, in 199 newly...
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