Article
Similar clinical features in follicular lymphomas with and without breaks in the BCL2 locus.
Leukemia - 1 Apr 2016
Leich E, Hoster E, Wartenberg M, Unterhalt M, Siebert R, Koch K, Klapper W, Engelhard M, Puppe B, Horn H, Staiger A M, Stuhlmann-Laeisz C, Bernd H W, Feller A C, Hummel M, Lenze D, Stein H, Hartmann S, Hansmann M L, Möller P, Hiddemann W, Dreyling M, Ott G, Rosenwald A
Abstract excerpt
Approximately 15% of follicular lymphomas (FLs) lack breaks in the BCL2 locus. The aim of this study was to better define molecular and clinical features of BCL2-breakpoint/t(14;18)-negative FLs. We studied the presence of BCL2, BCL6 and MYC breaks by fluorescence in situ hybridization and the expression of BCL2, MUM1, CD10, P53 and Ki67 in large clinical trial cohorts of 540 advanced-stage FL cases and 116...
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