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Article

Sonic Hedgehog signaling impairs ionizing radiation–induced checkpoint activation and induces genomic instability

27 Oct 2008

Abstract excerpt

The Sonic Hedgehog (Shh) pathway plays important roles in embryogenesis, stem cell maintenance, tissue repair, and tumorigenesis. Haploinsufficiency of Patched-1, a gene that encodes a repressor of the Shh pathway, dysregulates the Shh pathway and increases genomic instability and the development of spontaneous and ionizing radiation (IR)-induced tumors by an unknown mechanism. Here we show that Ptc1(+/-) mice...

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PMID: 18955550
DOI: 10.1083/jcb.200804042

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