Article
Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia.
Blood - 1 Oct 2007
Kile Benjamin T, Panopoulos Athanasia D, Stirzaker Roslynn A, Hacking Douglas F, Tahtamouni Lubna H, Willson Tracy A, Mielke Lisa A, Henley Katya J, Zhang Jian-Guo, Wicks Ian P, Stevenson William S, Nurden Paquita, Watowich Stephanie S, Justice Monica J
Abstract excerpt
A pivotal mediator of actin dynamics is the protein cofilin, which promotes filament severing and depolymerization, facilitating the breakdown of existing filaments, and the enhancement of filament growth from newly created barbed ends. It does so in concert with actin interacting protein 1 (Aip1), which serves to accelerate cofilin's activity. While progress has been made in understanding its biochemical...
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