Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aip1p interacts with cofilin to disassemble actin filaments.

The Journal of cell biology - 14 Jun 1999

Rodal A A, Tetreault J W, Lappalainen P, Drubin D G, Amberg D C

Abstract excerpt

Actin interacting protein 1 (Aip1) is a conserved component of the actin cytoskeleton first identified in a two-hybrid screen against yeast actin. Here, we report that Aip1p also interacts with the ubiquitous actin depolymerizing factor cofilin. A two-hybrid-based approach using cofilin and actin mutants identified residues necessary for the interaction of actin, cofilin, and Aip1p in an apparent ternary complex....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actin Depolymerizing Factors
Share to Actins
Share to Antibodies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytoskeleton

Share to Genes, Lethal

Share to Microfilament Proteins

Share to Polymers

Share to Thermodynamics

Source

Open in PubMed Open full text

Identifiers

PMID: 10366597
DOI: 10.1083/jcb.145.6.1251
PMCID: PMC2133144

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aip1p interacts with cofilin to disassemble actin filaments.PMID 10366597Read ↗

Aip1 and cofilin promote rapid turnover of yeast actin patches and cables: a coordinated mechanism for severing and capping filaments.Semantic proximity Read ↗

Aip1 promotes actin filament severing by cofilin and regulates constriction of the cytokinetic contractile ring.Semantic proximity Read ↗

A genetic dissection of Aip1p's interactions leads to a model for Aip1p-cofilin cooperative activities.Semantic proximity Read ↗

Functions of actin-interacting protein 1 (AIP1)/WD repeat protein 1 (WDR1) in actin filament dynamics and cytoskeletal regulation.Semantic proximity Read ↗

Cooperation of two actin-binding proteins, cofilin and Aip1, in Saccharomyces cerevisiae.Semantic proximity Read ↗

Overlapping and distinct functions for cofilin, coronin and Aip1 in actin dynamics in vivo.Semantic proximity Read ↗

Enhancement of actin-depolymerizing factor/cofilin-dependent actin disassembly by actin-interacting protein 1 is required for organized actin filament assembly in the Caenorhabditis elegans body wall muscle.Semantic proximity Read ↗

Aip1p dynamics are altered by the R256H mutation in actin.Semantic proximity Read ↗

Identification of Functional Residues on Caenorhabditis elegans Actin-interacting Protein 1 (UNC-78) for Disassembly of Actin Depolymerizing Factor/Cofilin-bound Actin FilamentsSemantic proximity Read ↗

The two actin-interacting protein 1 genes have overlapping and essential function for embryonic development in Caenorhabditis elegans.Semantic proximity Read ↗

The flare gene, which encodes the AIP1 protein of Drosophila, functions to regulate F-actin disassembly in pupal epidermal cells.Semantic proximity Read ↗

Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.