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Article

Aip1 and cofilin promote rapid turnover of yeast actin patches and cables: a coordinated mechanism for severing and capping filaments.

Molecular biology of the cell - 1 Jul 2006

Okada Kyoko, Ravi Harini, Smith Ellen M, Goode Bruce L

Abstract excerpt

Rapid turnover of actin structures is required for dynamic remodeling of the cytoskeleton and cell morphogenesis, but the mechanisms driving actin disassembly are poorly defined. Cofilin plays a central role in promoting actin turnover by severing/depolymerizing filaments. Here, we analyze the in vivo function of a ubiquitous actin-interacting protein, Aip1, suggested to work with cofilin. We provide the first...

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Identifiers

PMID: 16611742
DOI: 10.1091/mbc.e06-02-0135
PMCID: PMC1483024

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Aip1 and cofilin promote rapid turnover of yeast actin patches and cables: a coordinated mechanism for severing and capping filaments.PMID 16611742Read ↗

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