Article
Molecular basis of a linkage peak: exome sequencing and family-based analysis identify a rare genetic variant in the ADIPOQ gene in the IRAS Family Study.
Human molecular genetics - 15 Oct 2010
Bowden Donald W, An S Sandy, Palmer Nicholette D, Brown W Mark, Norris Jill M, Haffner Stephen M, Hawkins Gregory A, Guo Xiuqing, Rotter Jerome I, Chen Y-D Ida, Wagenknecht Lynne E, Langefeld Carl D
Abstract excerpt
Family-based linkage analysis has been a powerful tool for identification of genes contributing to traits with monogenic patterns of inheritance. These approaches have been of limited utility in identification of genes underlying complex traits. In contrast, searches for common genetic variants associated with complex traits have been highly successful. It is now widely recognized that common variations...
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