Article
Estimating the contributions of rare and common genetic variations and clinical measures to a model trait: adiponectin.
Genetic epidemiology - 1 Jan 2013
An S Sandy, Palmer Nicholette D, Hanley Anthony J G, Ziegler Julie T, Brown W Mark, Haffner Steven M, Norris Jill M, Rotter Jerome I, Guo Xiuqing, Chen Y-D Ida, Wagenknecht Lynne E, Langefeld Carl D, Bowden Donald W
Abstract excerpt
Common genetic variation frequently accounts for only a modest amount of interindividual variation in quantitative traits and complex disease susceptibility. Circulating adiponectin, an adipocytokine implicated in metabolic disease, is a model for assessing the contribution of genetic and clinical factors to quantitative trait variation. The adiponectin locus, ADIPOQ, is the primary source of genetically mediated...
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