Article
Deep resequencing unveils genetic architecture of ADIPOQ and identifies a novel low-frequency variant strongly associated with adiponectin variation.
Diabetes - 1 May 2012
Warren Liling L, Li Li, Nelson Matthew R, Ehm Margaret G, Shen Judong, Fraser Dana J, Aponte Jennifer L, Nangle Keith L, Slater Andrew J, Woollard Peter M, Hall Matt D, Topp Simon D, Yuan Xin, Cardon Lon R, Chissoe Stephanie L, Mooser Vincent, Morris Andrew D, Palmer Colin N A, Perry John R, Frayling Timothy M, Whittaker John C, Waterworth Dawn M
Abstract excerpt
Increased adiponectin levels have been shown to be associated with a lower risk of type 2 diabetes. To understand the relations between genetic variation at the adiponectin-encoding gene, ADIPOQ, and adiponectin levels, and subsequently its role in disease, we conducted a deep resequencing experiment of ADIPOQ in 14,002 subjects, including 12,514 Europeans, 594 African Americans, and 567 Indian Asians. We...
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