Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences.

doi:10.1371/journal.pgen.1009019

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Article

Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences.

PLoS genetics - 1 Sept 2020

Spracklen Cassandra N, Iyengar Apoorva K, Vadlamudi Swarooparani, Raulerson Chelsea K, Jackson Anne U, Brotman Sarah M, Wu Ying, Cannon Maren E, Davis James P, Crain Aaron T, Currin Kevin W, Perrin Hannah J, Narisu Narisu, Stringham Heather M, Fuchsberger Christian, Locke Adam E, Welch Ryan P, Kuusisto Johanna K, Pajukanta Päivi, Scott Laura J, Li Yun, Collins Francis S, Boehnke Michael, Laakso Markku, Mohlke Karen L

Abstract excerpt

Loci identified in genome-wide association studies (GWAS) can include multiple distinct association signals. We sought to identify the molecular basis of multiple association signals for adiponectin, a hormone involved in glucose regulation secreted almost exclusively from adipose tissue, identified in the Metabolic Syndrome in Men (METSIM) study. With GWAS data for 9,262 men, four loci were significantly...

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Identifiers

PMID: 32915782
DOI: 10.1371/journal.pgen.1009019
PMCID: PMC7511027

Genes

ADIPOQ
CDH13
IRS1
PBRM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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