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Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains

21 May 2007

Abstract excerpt

Factor H (FH) is an abundant serum glycoprotein that regulates the alternative pathway of complement-preventing uncontrolled plasma C3 activation and nonspecific damage to host tissues. Age-related macular degeneration (AMD), atypical hemolytic uremic syndrome (aHUS), and membranoproliferative glomerulonephritis type II (MPGN2) are associated with polymorphisms or mutations in the FH gene (Cfh), suggesting the...

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Complement system in diseases
Renal Diseases and Glomerulopathies
Retinal Diseases and Treatments

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17517971
DOI: 10.1084/jem.20070301

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